Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
J Endocrinol Invest. 2011 Jul-Aug;34(7):e178-82. doi: 10.3275/7352. Epub 2010 Nov 16.
Early atherosclerosis and increased risk of cardiovascular diseases (CVD) have been reported in patients with polycystic ovary syndrome (PCOS). Oxidative stress is an accepted risk factor for the development of CVD.
To evaluate the association between oxidative stress markers [ischemia-modified albumin (IMA), total antioxidant status (TAS), and total oxidant status (TOS) levels], carotid intima- media thickness (CIMT), endocrine and metabolic parameters in patients with PCOS. MATERIALS, SUBJECTS, AND METHODS: We studied 52 patients with PCOS and 36 age- and body mass index (BMI)-matched controls. The diagnosis of PCOS was made according to the Rotterdam criteria. Metabolic, hormonal parameter and IMA, TAS, TOS levels were measured.
No statistically significant difference was determined in relation to age, BMI and waist-hip ratio, IMA, TAS, and TOS levels between groups. Mean IMA level was higher in PCOS patients, however, statistical significant difference was not observed. Mean CIMT and homeostasis model assessment of insulin resistance levels were significantly higher in patients with PCOS than in control subjects.
Our study has shown that although CIMT levels, showing CVD risk, were higher in PCOS patients, TAS and TOS oxidative stress markers were found to be similar between groups, IMA was higher in PCOS patients however the difference was not reach statistical significant. The present results suggest that CIMT increases before the state of ischemia and shows preischemic state of vasculature, while oxidative stress markers are considered to be indicators of ischemia and reperfusion injury in progressive vascular disease. Further studies are needed to show the association between oxidative stress markers, CVD and PCOS.
多囊卵巢综合征（PCOS）患者存在早期动脉粥样硬化和心血管疾病（CVD）风险增加。氧化应激是 CVD 发展的公认危险因素。
评估氧化应激标志物[缺血修饰白蛋白（IMA）、总抗氧化状态（TAS）和总氧化状态（TOS）水平]与 PCOS 患者颈动脉内膜中层厚度（CIMT）、内分泌和代谢参数之间的关系。
材料、受试者和方法：我们研究了 52 例 PCOS 患者和 36 名年龄和体重指数（BMI）匹配的对照组。根据鹿特丹标准诊断 PCOS。测量代谢、激素参数和 IMA、TAS、TOS 水平。
两组间年龄、BMI 和腰臀比、IMA、TAS 和 TOS 水平无统计学差异。PCOS 患者的平均 IMA 水平较高，但无统计学差异。PCOS 患者的平均 CIMT 和稳态模型评估的胰岛素抵抗水平明显高于对照组。
我们的研究表明，尽管 PCOS 患者的 CIMT 水平较高，表明存在 CVD 风险，但两组间的 TAS 和 TOS 氧化应激标志物无差异，PCOS 患者的 IMA 较高，但差异无统计学意义。目前的结果表明，CIMT 在发生缺血之前增加，并显示血管的缺血前状态，而氧化应激标志物被认为是进展性血管疾病中缺血再灌注损伤的指标。需要进一步的研究来显示氧化应激标志物、CVD 和 PCOS 之间的关系。
