热休克蛋白是骨骼肌胰岛素敏感性的重要介质。
Heat shock proteins are important mediators of skeletal muscle insulin sensitivity.
机构信息
University of Kansas Medical Center, Department of Molecular and Integrative Physiology, Kansas City, KS 66160, USA.
出版信息
Exerc Sport Sci Rev. 2011 Jan;39(1):34-42. doi: 10.1097/JES.0b013e318201f236.
Abstract
Endogenous heat shock proteins (HSP) are decreased in disease states associated with insulin resistance and aging. Induction of HSPs has been shown to decrease oxidative stress, inhibit inflammatory pathways, and enhance metabolic characteristics in skeletal muscle. As such, HSPs have the potential to function as an important defense system against the development of insulin resistance and type 2 diabetes.
摘要
内源性热休克蛋白 (HSP) 在与胰岛素抵抗和衰老相关的疾病状态下减少。已经表明，诱导 HSP 可以减少氧化应激、抑制炎症途径，并增强骨骼肌的代谢特性。因此，HSP 有可能作为抵抗胰岛素抵抗和 2 型糖尿病发展的重要防御系统发挥作用。
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