Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan, Michigan 48109, USA.
Nat Rev Immunol. 2010 Dec;10(12):826-37. doi: 10.1038/nri2873. Epub 2010 Nov 19.
Over the past several decades, much has been revealed about the nature of the host innate immune response to microorganisms, with the identification of pattern recognition receptors (PRRs) and pathogen-associated molecular patterns, which are the conserved microbial motifs sensed by these receptors. It is now apparent that these same PRRs can also be activated by non-microbial signals, many of which are considered as damage-associated molecular patterns. The sterile inflammation that ensues either resolves the initial insult or leads to disease. Here, we review the triggers and receptor pathways that result in sterile inflammation and its impact on human health.
在过去的几十年中，人们对宿主固有免疫对微生物的性质有了更多的了解，其中包括模式识别受体 (PRRs) 和病原体相关分子模式，这些都是这些受体感知到的保守微生物基序。现在很明显，这些相同的 PRRs 也可以被非微生物信号激活，其中许多被认为是损伤相关分子模式。随之而来的无菌性炎症要么消除初始损伤，要么导致疾病。在这里，我们回顾了导致无菌性炎症的触发因素和受体途径及其对人类健康的影响。
