Kiyama T, Onda M, Tokunaga A, Nishi K, Mizutani T, Yoshiyuki T, Shimizu Y, Matsukura N, Tanaka N, Asano G
First Department of Surgery, Nippon Medical School, Tokyo.
Jpn J Cancer Res. 1990 Jan;81(1):58-62. doi: 10.1111/j.1349-7006.1990.tb02507.x.
We established a human gastric cancer xenograft which, when inoculated into nude mice, showed a positive correlation between tumor growth and the serum level of carcinoembryonic antigen (CEA). Serum CEA levels in the mice rose continuously with increasing tumor weight after inoculation, showing a correlation coefficient of 0.96. A positive correlation was also observed between the tissue CEA level and tumor weight, the former increasing along with the latter. Furthermore, the level of serum CEA closely paralleled that of tissue CEA. The serum CEA level fell after tumor extirpation, with a half-life of approximately 86 h. These results suggest that the elevation of serum CEA is attributable to the gain in tumor weight as well as the increase of CEA production in the tumor tissue. Thus, human gastric cancer xenografts in nude mice are a good model for examining the biological role of CEA.
我们建立了一种人胃癌异种移植模型，将其接种到裸鼠体内后，肿瘤生长与血清癌胚抗原（CEA）水平呈正相关。接种后，小鼠血清CEA水平随肿瘤重量增加而持续升高，相关系数为0.96。组织CEA水平与肿瘤重量之间也观察到正相关，前者随后者增加而升高。此外，血清CEA水平与组织CEA水平密切平行。肿瘤切除后血清CEA水平下降，半衰期约为86小时。这些结果表明，血清CEA升高归因于肿瘤重量增加以及肿瘤组织中CEA产生增加。因此，裸鼠体内的人胃癌异种移植模型是研究CEA生物学作用的良好模型。
