水螅外胚层上皮干细胞的终末分化可以在G2期发生，而不需要有丝分裂或S期。
Terminal differentiation of ectodermal epithelial stem cells of Hydra can occur in G2 without requiring mitosis or S phase.
作者信息
Dübel S, Schaller H C
机构信息
Zentrum für Molekulare Biologie Heidelberg, FRG.
出版信息
J Cell Biol. 1990 Apr;110(4):939-45. doi: 10.1083/jcb.110.4.939.
Abstract
Using bromodeoxyuridine incorporation to label cells in S phase we found that ectodermal epithelial cells of Hydra can start and complete their terminal differentiation in the G2 phase of the cell cycle. Most of the cells traversed their last S phase before the signal for differentiation, namely excision of head or foot, was given. The S phase inhibitor aphidicolin accordingly did not inhibit head or foot specific differentiation. The results show that differentiation to either head- or foot-specific ectodermal epithelial cells can start and is completed within the same G2 phase. This is therefore the first description of a complete differentiation from a population of proliferating cells to terminally differentiated, cell cycle-arrested cells without the necessity of passing through an S phase or mitosis.
摘要
利用溴脱氧尿苷掺入法标记处于S期的细胞，我们发现水螅的外胚层上皮细胞能够在细胞周期的G2期开始并完成其终末分化。大多数细胞在分化信号（即头部或足部切除）发出之前就已完成最后一次S期。因此，S期抑制剂阿非科林并不抑制头部或足部的特异性分化。结果表明，向头部或足部特异性外胚层上皮细胞的分化能够在同一G2期开始并完成。因此，这是首次描述从一群增殖细胞到终末分化、细胞周期停滞细胞的完全分化，而无需经过S期或有丝分裂。
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