Messinis I E, Templeton A A
Department of Obstetrics and Gynaecology, University of Aberdeen, Foresterhill, UK.
Hum Reprod. 1990 Feb;5(2):150-2. doi: 10.1093/oxfordjournals.humrep.a137059.
The effect of clomiphene on the pituitary response to exogenous LHRH was investigated in five hypogonadal women during long-term treatment with varying doses of oestrogen. In three of them, basal LH levels were low (less than 10 mIU/ml) and increased significantly after 8 days of treatment with clomiphene (100 mg/day). Clomiphene augmented the LH and FSH response to LHRH (an acute i.v. injection of 100 micrograms) and changed the pattern of response into that seen in the absence of the influence of ovarian steroids. We conclude that clomiphene exerts anti-oestrogenic effects on basal and LHRH-stimulated release of gonadotrophins in hypogonadal women during long-term treatment with oestrogen.
在五名性腺功能减退的女性长期接受不同剂量雌激素治疗期间，研究了克罗米芬对外源性促黄体生成素释放激素（LHRH）引起的垂体反应的影响。其中三名女性，基础促黄体生成素（LH）水平较低（低于10 mIU/ml），在接受克罗米芬（100 mg/天）治疗8天后显著升高。克罗米芬增强了对LHRH（静脉内急性注射100微克）的LH和促卵泡生成素（FSH）反应，并将反应模式改变为在无卵巢类固醇影响时所见的模式。我们得出结论，在长期接受雌激素治疗的性腺功能减退女性中，克罗米芬对基础和LHRH刺激的促性腺激素释放具有抗雌激素作用。
