Ren Xiumin, Yang Yanzhong, Duan Naichao, Jiang Xinxia, He Qiang
Department of Otorhinolaryngology, the Second Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050000, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Sep;24(17):772-5.
To study the effect of intranasal glucosteroid on the expression of PKC, Bcl-2 and Bax in nasal polyps.
The expression of PKC, Bcl-2 protein and Bax were detected with immunohistochemistry in nasal polyps from the patients (n=16) pre and post treated for 4 weeks with intranasal glucosteroid. And which compared with normal mucous membrane of inferior turbinate concha.
The PKC and Bcl-2 protein expressed significantly higher in the pretreated patients (P < 0.01), which were significant reduced in the post treated patients compared with pretreated ones. The expression of Bax protein significantly higher in the post treated patients (P < 0.05).
Our findings indicated that abnormal expression of apoptosis related genes in nasal polyps tissues might play an important role in the occurrence and progression of nasal polyps. The treatment of intranasal glucosteroid may regulate the expression of apoptosis related genes.
研究鼻内糖皮质激素对鼻息肉中蛋白激酶C（PKC）、Bcl-2和Bax表达的影响。
采用免疫组织化学法检测16例患者鼻息肉在鼻内糖皮质激素治疗4周前后PKC、Bcl-2蛋白和Bax的表达，并与下鼻甲正常黏膜进行比较。
治疗前患者PKC和Bcl-2蛋白表达显著升高（P < 0.01），治疗后患者与治疗前相比显著降低。治疗后患者Bax蛋白表达显著升高（P < 0.05）。
我们的研究结果表明，鼻息肉组织中凋亡相关基因的异常表达可能在鼻息肉的发生和发展中起重要作用。鼻内糖皮质激素治疗可能调节凋亡相关基因的表达。
