Catalysis Research Center and Graduate School of Life Science, Hokkaido University, Kita-ku, Sapporo 001-0021, Japan.
Org Lett. 2010 Dec 17;12(24):5736-9. doi: 10.1021/ol102554a. Epub 2010 Nov 19.
Stepwise application of the Pd-catalyzed S(N)2' reaction and the desilylative S(E)2' reaction to the ambivalent 2-bromo-1-silyl-1,3-dienes provides a novel route to the highly enantioselective construction of tertiary and quaternary propargylic stereogenic centers via axially chiral allenylsilanes.
逐步应用钯催化的 S(N)2' 反应和脱硅基 S(E)2' 反应于双官能团 2-溴-1-硅基-1,3-二烯，提供了一种通过轴手性烯丙基硅烷高对映选择性构建三级和四级炔丙基立体中心的新途径。
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