钯催化1,1 - 二溴烯烃、氯乙烯基锌与软亲核试剂的三组分偶联反应：1,3 - 二取代丙二烯的一锅法合成
Palladium-Catalyzed Three-Component Coupling of 1,1-Dibromoalkenes, Vinylzinc Chloride, and Soft Nucleophiles: One-Pot Synthesis of 1,3-Disubstituted Allenes.
作者信息
Sawano Eri, Ogasawara Masamichi
机构信息
Department of Natural Science, Graduate School of Science and Technology and Research Cluster on "Innovative Chemical Sensing", Tokushima University, Tokushima 770-8506, Japan.
Graduate School of Life Science, Hokkaido University, Kita-ku, Sapporo 001-0021, Japan.
出版信息
ACS Omega. 2019 Nov 8;4(21):19499-19504. doi: 10.1021/acsomega.9b03444. eCollection 2019 Nov 19.
The three-component coupling reaction of 1,1-dibromoalkenes , vinylzinc chloride , and carbon soft nucleophiles was realized in the presence of the catalytic palladium/Xantphos species, and 1,3-disubstituted allenic products were obtained in yields of up to 77%. The successive two palladium-catalyzed processes, namely the cross-coupling reaction and the allylic substitution, assembled from the easily accessible starting compounds.
在催化钯/联二萘酚膦物种存在下实现了1,1-二溴烯烃、乙烯基氯化锌和碳软亲核试剂的三组分偶联反应，得到了产率高达77%的1,3-二取代丙二烯产物。由易于获得的起始化合物组装而成的连续两个钯催化过程，即交叉偶联反应和烯丙基取代反应。
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