一种使用金催化的亲核加成到烯酰胺来制备内酰胺的简便温和的合成方法。
A facile and mild synthesis of enamides using a gold-catalyzed nucleophilic addition to allenamides.
机构信息
Department of Chemistry, Loughborough University, Leicestershire LE11 3TU, UK.
出版信息
Org Lett. 2010 Mar 5;12(5):1128-31. doi: 10.1021/ol1001494.
PMID:20143846
Abstract
A mild and facile synthesis of enamides has been developed, based on nucleophilic addition of electron-rich aromatic and heteroaromatics to an allenamide unit catalyzed by a gold salt. Yields for the transformation were 29-98%.
摘要
一种温和且简便的烯酰胺合成方法已经开发出来，该方法基于富电子芳香族和杂芳香族化合物在金盐催化下与烯丙酰胺单元的亲核加成。该转化的产率为 29-98%。
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