University of Texas at Austin, Department of Chemistry and Biochemistry, Austin, Texas 78712, USA.
Org Lett. 2010 Jun 4;12(11):2514-6. doi: 10.1021/ol1007235.
Exposure of alcohols to allenamides in the presence of RuHCl(CO)(PPh(3))(3) and dippf [dippf = bis(diisopropylphosphino)ferrocene] results in hydrogen transfer to generate aldehyde-allylruthenium pairs, which engage in C-C coupling to form products of carbonyl aminoallylation as single anti-diastereomers.
醇在 RuHCl(CO)(PPh(3))(3) 和 dippf(二异丙基膦二茂铁)存在下与烯丙酰胺接触会发生氢转移,生成醛-烯丙基钌对,它们进行 C-C 偶联形成羰基氨基烯丙化产物的单非对映异构体。