体内靶向乳腺癌的多模态治疗性纳米复合物的追踪。
Tracking of multimodal therapeutic nanocomplexes targeting breast cancer in vivo.
机构信息
Department of Chemistry, Rice University, Houston, Texas 77005, United States.
出版信息
Nano Lett. 2010 Dec 8;10(12):4920-8. doi: 10.1021/nl102889y. Epub 2010 Nov 22.
Abstract
Nanoparticle-based therapeutics with local delivery and external electromagnetic field modulation holds extraordinary promise for soft-tissue cancers such as breast cancer; however, knowledge of the distribution and fate of nanoparticles in vivo is crucial for clinical translation. Here we demonstrate that multiple diagnostic capabilities can be introduced in photothermal therapeutic nanocomplexes by simultaneously enhancing both near-infrared fluorescence and magnetic resonance imaging (MRI). We track nanocomplexes in vivo, examining the influence of HER2 antibody targeting on nanocomplex distribution over 72 h. This approach provides valuable, detailed information regarding the distribution and fate of complex nanoparticles designed for specific diagnostic and therapeutic functions.
摘要
基于纳米颗粒的治疗方法，通过局部递药和外部电磁场调节，为软组织癌症（如乳腺癌）带来了非凡的前景；然而，了解纳米颗粒在体内的分布和归宿对于临床转化至关重要。在这里，我们通过同时增强近红外荧光和磁共振成像（MRI），证明了光热治疗纳米复合物可以引入多种诊断能力。我们在体内追踪纳米复合物，研究 HER2 抗体靶向对纳米复合物分布的影响，持续 72 小时。这种方法为特定诊断和治疗功能而设计的复杂纳米颗粒的分布和归宿提供了有价值的详细信息。
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