Université de Strasbourg, CNRS, CAMB UMR 7199, F-67000, Strasbourg, France.
Pharm Res. 2019 Apr 3;36(6):78. doi: 10.1007/s11095-019-2608-5.
This review article presents the state-of-the-art in the major imaging modalities supplying relevant information on patient health by real-time monitoring to establish an accurate diagnosis and potential treatment plan. We draw a comprehensive comparison between all imagers and ultimately end with our focus on two main types of scanners: X-ray CT and MRI scanners. Numerous types of imaging probes for both imaging techniques are described, as well as reviewing their strengths and limitations, thereby showing the current need for the development of new diagnostic contrast agents (CAs). The role of nanoparticles in the design of CAs is then extensively detailed, reviewed and discussed. We show how nanoparticulate agents should be promising alternatives to molecular ones and how they are already paving new routes in the field of nanomedicine.
这篇综述文章介绍了主要成像方式的最新技术，这些方式通过实时监测提供有关患者健康的相关信息，以建立准确的诊断和潜在的治疗计划。我们对所有成像仪进行了全面比较，最终将重点放在两种主要类型的扫描仪上：X 射线 CT 和 MRI 扫描仪。描述了这两种成像技术的多种成像探针，并审查了它们的优缺点，从而表明当前需要开发新的诊断造影剂（CA）。然后，详细、审查和讨论了纳米粒子在 CA 设计中的作用。我们展示了纳米颗粒剂如何成为分子剂的有前途的替代品，以及它们如何在纳米医学领域开辟新的途径。
