Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52074 Aachen, Germany.
Org Lett. 2010 Dec 17;12(24):5680-3. doi: 10.1021/ol102499r. Epub 2010 Nov 23.
A catalytic enantioselective synthesis of dihydrofurans has been developed. 1,3-Dicarbonyl derivatives react with (E)-β,β-bromonitrostyrenes in the presence of a chiral bifunctional thiourea catalyst providing mild and efficient access to diverse polysubstituted dihydrofurans in good yields and enantioselectivities.
已开发出一种催化对映选择性合成二氢呋喃的方法。在手性双功能硫脲催化剂的存在下，1,3-二羰基衍生物与（E）-β,β-溴代亚硝基苯乙烯反应，以良好的收率和对映选择性温和有效地提供了各种多取代的二氢呋喃。
