Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea.
J Nat Prod. 2011 Jan 28;74(1):54-9. doi: 10.1021/np100660v. Epub 2010 Dec 23.
Twelve new tirucallane triterpenoids, named cornusalterins A-L (1-12), and two known tirucallane triterpenoids, deoxyflindissone (13) and (-)-leucophyllone (14), were isolated from a MeOH extract of stems and stem bark of Cornus walteri. The structures of the new compounds were determined by spectroscopic methods, including 1D and 2D NMR analyses. Compounds 12 and 13, possessing a tetrahydrofuran ring in the side chain, exhibited significant cytotoxic activity against the A549, SK-OV-3, SK-MEL-2, and XF498 cell lines.
从 Cornus walteri 的茎和茎皮的甲醇提取物中分离得到了 12 种新的三萜类化合物，命名为 cornusalterins A-L（1-12），以及两种已知的三萜类化合物，deoxyflindissone（13）和（-）-leucophyllone（14）。通过光谱方法，包括 1D 和 2D NMR 分析，确定了新化合物的结构。具有四氢呋喃环的化合物 12 和 13，在侧链上，对 A549、SK-OV-3、SK-MEL-2 和 XF498 细胞系表现出显著的细胞毒性活性。
