Pilz Stefan, Tomaschitz Andreas
Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Austria.
Expert Rev Cardiovasc Ther. 2010 Nov;8(11):1599-608. doi: 10.1586/erc.10.142.
Vitamin D deficiency is highly prevalent and may contribute to arterial hypertension. The antihypertensive effects of vitamin D include suppression of renin and parathyroid hormone levels and renoprotective, anti-inflammatory and vasculoprotective properties. Low 25-hydroxyvitamin D levels, which are used to classify the vitamin D status, are an independent risk factor for incident arterial hypertension. Meta-analyses of randomized controlled trials showed that vitamin D supplementation reduces systolic blood pressure by 2-6 mmHg. However, further studies are needed before drawing a final conclusion on the effect of vitamin D therapy on blood pressure and cardiovascular risk. In our current clinical practice we should take into account the high prevalence of vitamin D deficiency, the easy, cheap and safe way by which it can be supplemented and the promising clinical data suggesting that vitamin D might be useful for the treatment of arterial hypertension as well as other chronic diseases. Therefore, we recommend that testing for and treating vitamin D deficiency in patients with arterial hypertension should be seriously considered.
维生素D缺乏症非常普遍，可能会导致动脉高血压。维生素D的降压作用包括抑制肾素和甲状旁腺激素水平，以及具有肾脏保护、抗炎和血管保护特性。用于分类维生素D状态的低25-羟基维生素D水平是发生动脉高血压的独立危险因素。随机对照试验的荟萃分析表明，补充维生素D可使收缩压降低2-6 mmHg。然而，在就维生素D治疗对血压和心血管风险的影响得出最终结论之前，还需要进一步研究。在我们目前的临床实践中，我们应考虑到维生素D缺乏症的高患病率、补充维生素D简便、廉价且安全的方式，以及表明维生素D可能对治疗动脉高血压和其他慢性疾病有用的有前景的临床数据。因此，我们建议应认真考虑对动脉高血压患者进行维生素D缺乏症检测和治疗。
