Anandabaskar Nishanthi, Selvarajan Sandhiya, Dkhar Steven Aibor, Kamalanathan Sadish Kumar, Tamilarasu Kadhiravan, Bobby Zachariah
Department of Pharmacology, JIPMER, Puducherry, India.
Department of Clinical Pharmacology, JIPMER, Puducherry, India.
Indian J Endocrinol Metab. 2017 Jul-Aug;21(4):555-563. doi: 10.4103/ijem.IJEM_140_17.
Vitamin D levels are reported to have an inverse liaison with the risk of cardiovascular diseases. Hence, we aimed to evaluate the effect of Vitamin D supplementation on changes in vascular functions and oxidative stress in type 2 diabetic patients with Vitamin D deficiency.
One hundred and three patients with type 2 diabetes attending endocrinology outpatients department in a tertiary care hospital were screened for Vitamin D deficiency. Patients with serum 25-hydroxy Vitamin D levels <20 ng/ml were considered as deficient and were administered 60,000 IU of oral Vitamin D weekly for 8 weeks. In these patients, parameters of vascular functions (carotid-femoral pulse wave velocity, brachial-ankle pulse wave velocity, and arterial stiffness index) and oxidative stress (serum malondialdehyde levels and total antioxidant status) were measured at baseline and after 8 weeks of oral Vitamin D supplementation.
Among 103 patients with type 2 diabetes, 75 (72.82%) were found to have Vitamin D deficiency. Amidst these patients, carotid-femoral pulse wave velocity (991.6 ± 161.82 vs. 899.29 ± 151.86, < 0.001), right brachial-ankle pulse wave velocity (1446.16 ± 204.33 vs. 1350.8 ± 178.39, < 0.001), and left brachial-ankle pulse wave velocity (1493.81 ± 219.65 vs. 1367.61 ± 220.64, < 0.001) showed a significant reduction following Vitamin D supplementation. Further, these patients were found to have significant fall in serum malondialdehyde levels with rise in total antioxidant status ensuing Vitamin D supplementation.
The present study shows that oral Vitamin D supplementation of 60,000 IU/week for 8 weeks significantly improves vascular functions and reduces oxidative stress in type 2 diabetic patients with Vitamin D deficiency.
据报道，维生素D水平与心血管疾病风险呈负相关。因此，我们旨在评估补充维生素D对维生素D缺乏的2型糖尿病患者血管功能和氧化应激变化的影响。
在一家三级护理医院的内分泌门诊对103例2型糖尿病患者进行维生素D缺乏筛查。血清25-羟基维生素D水平<20 ng/ml的患者被视为维生素D缺乏，并每周口服60,000 IU维生素D，持续8周。在这些患者中，在基线时以及口服维生素D补充剂8周后测量血管功能参数（颈股脉搏波速度、臂踝脉搏波速度和动脉僵硬度指数）和氧化应激参数（血清丙二醛水平和总抗氧化状态）。
在103例2型糖尿病患者中，75例（72.82%）被发现存在维生素D缺乏。在这些患者中，补充维生素D后，颈股脉搏波速度（991.6±161.82对899.29±151.86，<0.001）、右臂踝脉搏波速度（1446.16±204.33对1350.8±178.39，<0.001）和左臂踝脉搏波速度（1493.81±219.65对1367.61±220.64，<0.001）均显著降低。此外，这些患者在补充维生素D后血清丙二醛水平显著下降，总抗氧化状态上升。
本研究表明，每周口服60,000 IU维生素D，持续8周，可显著改善维生素D缺乏的2型糖尿病患者的血管功能并降低氧化应激。
