Department of Cardiology, Poznan University of Medical Sciences, Dluga Street ½, 61-848 Poznan, Poland.
Int J Mol Sci. 2017 Oct 27;18(11):2252. doi: 10.3390/ijms18112252.
Cardiovascular diseases are the leading cause of mortality worldwide. Therefore, a better understanding of their pathomechanisms and the subsequent implementation of optimal prophylactic and therapeutic strategies are of utmost importance. A growing body of evidence states that low-grade inflammation is a common feature for most of the cardiovascular diseases in which the contributing factors are the activation of toll-like receptors (TLRs) and vitamin D deficiency. In this article, available data concerning the association of cardiovascular diseases with TLRs and vitamin D status are reviewed, followed by a discussion of new possible approaches to cardiovascular disease management.
心血管疾病是全球范围内导致死亡的主要原因。因此，更好地了解其病理机制，并随后实施最佳的预防和治疗策略至关重要。越来越多的证据表明，低度炎症是大多数心血管疾病的共同特征，其促成因素是 Toll 样受体 (TLRs) 的激活和维生素 D 缺乏。本文综述了有关心血管疾病与 TLR 和维生素 D 状态相关性的现有数据，并讨论了管理心血管疾病的新的可能方法。
