Read Christine M
Family Planning NSW, Sydney, Australia.
Eur J Contracept Reprod Health Care. 2010 Dec;15 Suppl 2:S32-41. doi: 10.3109/13625187.2010.529969.
The practice of extending combined oral contraceptive use (COC) and eliminating or reducing the hormone free interval has been in use for many years. More recently a range of products with new dosing options has been developed and marketed. Women and physicians in developed countries are comfortable with and many prefer the use of extended COC regimens which provide an option to eliminate or reduce the frequency of regular withdrawal bleeding. The extension of active pill taking and the reduction or elimination of the hormone-free interval have been shown to be beneficial for women who experience menstrual cycle-related problems such as heavy bleeding or dysmenorrhoea. The hormone-free interval of less than seven days has additional benefits in managing hormone withdrawal symptoms and efficacy may be improved in situations where pills are inadvertently missed or in women who are perceived as 'poor' pill takers. This paper provides a descriptive review highlighting the development of new dosing options that alter the traditional 21/7 COC regimen. The rationale for and the acceptability of COCs developed with alternative dosing regimens is examined.
延长复方口服避孕药（COC）的使用时间并消除或缩短无激素间隔的做法已应用多年。最近，一系列具有新给药方案的产品已被研发并推向市场。发达国家的女性和医生对延长COC方案感到满意，许多人更喜欢使用这种方案，因为它提供了一种消除或减少规律性撤退性出血频率的选择。延长服用活性药丸时间以及减少或消除无激素间隔已被证明对经历与月经周期相关问题（如月经过多或痛经）的女性有益。无激素间隔少于七天在管理激素撤退症状方面有额外益处，并且在意外漏服药丸的情况下或在被认为是“服药依从性差”的女性中，疗效可能会提高。本文进行了描述性综述，重点介绍了改变传统21/7 COC方案的新给药方案的发展情况。研究了采用替代给药方案开发的COC的原理和可接受性。
