Interdisciplinary Course of Science for Aging, Graduate School, Yonsei University, Seoul, Republic of Korea.
J Med Food. 2010 Dec;13(6):1307-12. doi: 10.1089/jmf.2010.1075.
The present study aimed to determine the effect of black soy peptide supplementation on glucose control in subjects with prediabetes (impaired fasting glucose or impaired glucose tolerance) and newly diagnosed type 2 diabetes mellitus (DM). In this double-blind, placebo-controlled study, subjects with prediabetes and type 2 DM were randomly assigned to the placebo control group or the black soy peptide intervention group. We determined fasting serum concentrations of glucose, hemoglobin A1c, insulin, and free fatty acids, performed a 2-hour postload glucose (2-hour PG) test, and compared serum lipid profiles before and after the 12-week supplementation. In particular, subjects with fasting glucose ≥ 110 mg/dL who consumed black soy peptides tended to have lower fasting glucose levels (two-tailed test, P = .098; one-tailed test, P = .049) and had a significant reduction in 2-hour PG level (two-tailed P = .012, one-tailed P = .006), compared with baseline levels. The changes in 2-hour PG levels were also statistically significant in the intervention group (-41.25 ± 13.67 mg/dL) compared with the placebo group (12.42 ± 9.80 mg/dL; two-tailed P = .015, one-tailed P = .008). In contrast, hemoglobin A1c levels were not significantly improved by the dietary intervention. In conclusion, black soy peptide supplementation may be beneficial for controlling fasting blood glucose levels and 2-hour PG levels.
本研究旨在探讨黑大豆肽补充对糖尿病前期（空腹血糖受损或糖耐量受损）和新诊断 2 型糖尿病患者血糖控制的影响。在这项双盲、安慰剂对照研究中，糖尿病前期和 2 型糖尿病患者被随机分配到安慰剂对照组或黑大豆肽干预组。我们测定了空腹血清葡萄糖、糖化血红蛋白 A1c、胰岛素和游离脂肪酸浓度，进行了 2 小时餐后血糖（2-hour PG）测试，并比较了 12 周补充前后的血清脂质谱。特别是空腹血糖≥110mg/dL 的受试者在食用黑大豆肽后，空腹血糖水平（双侧检验，P=0.098；单侧检验，P=0.049）和 2 小时 PG 水平（双侧 P=0.012，单侧 P=0.006）有降低趋势，与基线相比。与安慰剂组（12.42±9.80mg/dL）相比，干预组的 2 小时 PG 水平变化也具有统计学意义（-41.25±13.67mg/dL；双侧 P=0.015，单侧 P=0.008）。相反，饮食干预对糖化血红蛋白 A1c 水平没有显著改善。总之，黑大豆肽补充可能有益于控制空腹血糖水平和 2 小时 PG 水平。
