Williams Michelle A, Gelaye Bizu, Qiu Chunfang, Fida Neway, May Cripe Swee
Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA.
J Asthma. 2011 Feb;48(1):91-7. doi: 10.3109/02770903.2010.535882. Epub 2010 Nov 24.
Obstructive sleep apnea (OSA) or habitual snoring and asthma are known comorbid conditions in men and non-pregnant women. This comorbidity has not been evaluated among pregnant women. We assessed the habitual snoring-asthma relationship among pregnant women.
A cohort of women (N = 1335) were interviewed during pregnancy, and we ascertained participants' asthma status and collected information about habitual snoring, before and during pregnancy. Logistic regression procedures were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
Compared with non-asthmatics, the adjusted OR among asthmatics for snoring before pregnancy was 2.13 (95% CI 1.10-4.12). The odds of snoring during early pregnancy was 1.79-fold (OR = 1.79; 95% C; 1.07-3.01). Associations were more pronounced among overweight (≥ 25 kg/m(2)) asthmatics (OR = 5.39; 95% CI 2.27-12.75).
We report a cross-sectional association of habitual snoring and asthma among pregnant women. If confirmed, pregnant asthmatics may benefit from more vigilant screening and management of OSA or habitual snoring during pregnancy.
阻塞性睡眠呼吸暂停（OSA）或习惯性打鼾与哮喘是男性和非孕女性中已知的共病情况。这种共病情况尚未在孕妇中进行评估。我们评估了孕妇中习惯性打鼾与哮喘的关系。
对一组女性（N = 1335）在孕期进行访谈，确定参与者的哮喘状况，并收集孕前和孕期习惯性打鼾的信息。采用逻辑回归程序估计比值比（OR）和95%置信区间（CI）。
与非哮喘患者相比，哮喘患者孕前打鼾的校正OR为2.13（95%CI 1.10 - 4.12）。孕早期打鼾的几率为1.79倍（OR = 1.79；95%CI 1.07 - 3.01）。超重（≥25 kg/m²）的哮喘患者中关联更为明显（OR = 5.39；95%CI 2.27 - 12.75）。
我们报告了孕妇中习惯性打鼾与哮喘的横断面关联。如果得到证实，孕期哮喘患者可能会从孕期对OSA或习惯性打鼾更密切的筛查和管理中获益。
