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本文引用的文献

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Antiangiogenic agents and targets: A perspective.抗血管生成药物及其靶点：一个视角。
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The expression of sphingosine kinase-1 in head and neck carcinoma.鞘氨醇激酶-1 在头颈部癌中的表达。
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3
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.鞘氨醇-1-磷酸是 E3 泛素连接酶 TRAF2 的缺失辅因子。
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An update on sphingosine-1-phosphate and other sphingolipid mediators.鞘氨醇-1-磷酸和其他鞘脂类介质的最新进展。
Nat Chem Biol. 2010 Jul;6(7):489-97. doi: 10.1038/nchembio.392.
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Sphingosine 1-phosphate and cancer.鞘氨醇 1-磷酸与癌症。
Nat Rev Cancer. 2010 Jul;10(7):489-503. doi: 10.1038/nrc2875. Epub 2010 Jun 17.
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Intravitreal bevacizumab in vascular pigment epithelium detachment as a result of subfoveal occult choroidal neovascularization in age-related macular degeneration.特立氟胺治疗多发性硬化症的安全性：真实世界研究的荟萃分析
Retina. 2010 Oct;30(9):1420-5. doi: 10.1097/IAE.0b013e3181d87e97.
7
RETRACTED: SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis.撤回：SphK1 调节与内毒素和多微生物脓毒症相关的促炎反应。
Science. 2010 Jun 4;328(5983):1290-4. doi: 10.1126/science.1188635.
8
Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells.鞘氨醇激酶 1 诱导人表皮生长因子受体 2 耐受，并防止在雌激素受体阳性乳腺癌细胞中对鞘氨醇 1-磷酸产生迁移表型。
Mol Cell Biol. 2010 Aug;30(15):3827-41. doi: 10.1128/MCB.01133-09. Epub 2010 Jun 1.
9
Endothelial functions of sphingosine-1-phosphate.1-磷酸鞘氨醇的内皮功能。
Cell Physiol Biochem. 2010;26(1):87-96. doi: 10.1159/000315109. Epub 2010 May 18.
10
Activation of sphingosine kinase-1 in cancer: implications for therapeutic targeting.鞘氨醇激酶-1 在癌症中的激活：治疗靶点的意义。
Curr Mol Pharmacol. 2010 Jun;3(2):53-65. doi: 10.2174/1874467211003020053.

鞘氨醇-1-磷酸抗体作为癌症和年龄相关性黄斑变性治疗的潜在药物。

Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.

机构信息

Lpath, Inc., 6335 Ferris Square, Suite A, San Diego, CA 92121, USA.

出版信息

Br J Pharmacol. 2011 Mar;162(6):1225-38. doi: 10.1111/j.1476-5381.2010.01118.x.

DOI:10.1111/j.1476-5381.2010.01118.x
PMID:21091645
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3058156/
Abstract

Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid thought to be dysregulated in a variety of disease conditions. In this review, we discuss the roles of S1P in cancer and in wet age-related macular degeneration. We also explore potential treatment strategies for these disorders, including the utility of anti-S1P antibodies acting as molecular sponges to neutralize dysregulated S1P in relevant tissues.

摘要

鞘氨醇-1-磷酸（S1P）是一种具有多种生物学活性的脂质，被认为在多种疾病状态中失调。在这篇综述中，我们讨论了 S1P 在癌症和湿性年龄相关性黄斑变性中的作用。我们还探讨了这些疾病的潜在治疗策略，包括作为分子海绵的抗 S1P 抗体的效用，以中和相关组织中失调的 S1P。