鞘氨醇-1-磷酸抗体作为癌症和年龄相关性黄斑变性治疗的潜在药物。
Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.
机构信息
Lpath, Inc., 6335 Ferris Square, Suite A, San Diego, CA 92121, USA.
出版信息
Br J Pharmacol. 2011 Mar;162(6):1225-38. doi: 10.1111/j.1476-5381.2010.01118.x.
Abstract
Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid thought to be dysregulated in a variety of disease conditions. In this review, we discuss the roles of S1P in cancer and in wet age-related macular degeneration. We also explore potential treatment strategies for these disorders, including the utility of anti-S1P antibodies acting as molecular sponges to neutralize dysregulated S1P in relevant tissues.
摘要
鞘氨醇-1-磷酸（S1P）是一种具有多种生物学活性的脂质，被认为在多种疾病状态中失调。在这篇综述中，我们讨论了 S1P 在癌症和湿性年龄相关性黄斑变性中的作用。我们还探讨了这些疾病的潜在治疗策略，包括作为分子海绵的抗 S1P 抗体的效用，以中和相关组织中失调的 S1P。
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