Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA.
Nutr Rev. 2010 Dec;68 Suppl 2:S112-8. doi: 10.1111/j.1753-4887.2010.00346.x.
Deficiencies of the vitamins folate, B(12) , and B(6) are associated with neurological and psychological dysfunction and with congenital defects. In the elderly, cognitive impairment and incident dementia may be related to the high prevalence of inadequate B vitamin status and to elevations of plasma homocysteine. Plausible mechanisms include homocysteine neurotoxicity, vasotoxicity, and impaired S-adenosylmethionine-dependent methylation reactions vital to central nervous system function. In light of this, it is imperative to find safe ways of improving vitamin B status in the elderly without exposing some individuals to undue risk.
维生素叶酸、B(12) 和 B(6) 的缺乏与神经和心理功能障碍以及先天性缺陷有关。在老年人中，认知障碍和痴呆的发生可能与维生素 B 状态不足的高患病率以及血浆同型半胱氨酸升高有关。合理的机制包括同型半胱氨酸神经毒性、血管毒性和依赖 S-腺苷甲硫氨酸的中央神经系统功能至关重要的甲基化反应受损。有鉴于此，必须找到安全的方法来改善老年人的维生素 B 状态，而不会使某些人面临不必要的风险。
