Wan Zhijie, Zheng Jianheng, Zhu Zhigang, Sang Lan, Zhu Jinwei, Luo Shizheng, Zhao Yixin, Wang Ruirui, Zhang Yicui, Hao Kun, Chen Liang, Du Jun, Kan Juntao, He Hua
Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Nutrilite Health Institute, Shanghai, China.
Front Nutr. 2022 Dec 13;9:1031502. doi: 10.3389/fnut.2022.1031502. eCollection 2022.
Vitamin B consists of a group of water-soluble micronutrients that are mainly derived from the daily diet. They serve as cofactors, mediating multiple metabolic pathways in humans. As an integrated part of human health, gut microbiota could produce, consume, and even compete for vitamin B with the host. The interplay between gut microbiota and the host might be a crucial factor affecting the absorbing processes of vitamin B. On the other hand, vitamin B supplementation or deficiency might impact the growth of specific bacteria, resulting in changes in the composition and function of gut microbiota. Together, the interplay between vitamin B and gut microbiota might systemically contribute to human health. In this review, we summarized the interactions between vitamin B and gut microbiota and tried to reveal the underlying mechanism so that we can have a better understanding of its role in human health.
维生素B由一组水溶性微量营养素组成，主要来源于日常饮食。它们作为辅助因子，介导人体中的多种代谢途径。作为人类健康的一个组成部分，肠道微生物群可以产生、消耗甚至与宿主竞争维生素B。肠道微生物群与宿主之间的相互作用可能是影响维生素B吸收过程的关键因素。另一方面，补充或缺乏维生素B可能会影响特定细菌的生长，导致肠道微生物群的组成和功能发生变化。维生素B与肠道微生物群之间的相互作用共同可能对人类健康产生系统性影响。在本综述中，我们总结了维生素B与肠道微生物群之间的相互作用，并试图揭示其潜在机制，以便我们能更好地理解其在人类健康中的作用。
