Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Nutr Rev. 2010 Dec;68 Suppl 2(Suppl 2):S88-101. doi: 10.1111/j.1753-4887.2010.00344.x.
Brain phosphatide synthesis requires three circulating compounds: docosahexaenoic acid (DHA), uridine, and choline. Oral administration of these phosphatide precursors to experimental animals increases the levels of phosphatides and synaptic proteins in the brain and per brain cell as well as the numbers of dendritic spines on hippocampal neurons. Arachidonic acid fails to reproduce these effects of DHA. If similar increases occur in human brain, administration of these compounds to patients with diseases that cause loss of brain synapses, such as Alzheimer's disease, could be beneficial.
二十二碳六烯酸(DHA)、尿苷和胆碱。向实验动物口服这些磷脂前体可提高大脑和每个脑细胞中的磷脂和突触蛋白水平以及海马神经元树突棘的数量。花生四烯酸不能重现 DHA 的这些作用。如果人类大脑也出现类似的增加,那么向患有导致脑突触丧失的疾病(如阿尔茨海默病)的患者施用这些化合物可能是有益的。