Haddad John J
Molecular Neuroscience Research Division, Department of Anesthesia and Perioperative Care, University of California at San Francisco, School of Medicine, San Francisco, CA 94143-0542, USA.
Cell Signal. 2002 Nov;14(11):879-97. doi: 10.1016/s0898-6568(02)00053-0.
A progressive rise of oxidative stress due to the altered reduction-oxidation (redox) homeostasis appears to be one of the hallmarks of the processes that regulate gene transcription in physiology and pathophysiology. Reactive oxygen (ROS) and nitrogen (RNS) species serve as signaling messengers for the evolution and perpetuation of the inflammatory process that is often associated with the condition of oxidative stress, which involves genetic regulation. Changes in the pattern of gene expression through ROS/RNS-sensitive regulatory transcription factors are crucial components of the machinery that determines cellular responses to oxidative/redox conditions. Transcription factors that are directly influenced by reactive species and pro-inflammatory signals include nuclear factor-kappaB (NF-kappaB) and hypoxia-inducible factor-1alpha (HIF-1alpha). Here, I describe the basic components of the intracellular oxidative/redox control machinery and its crucial regulation of oxygen- and redox-sensitive transcription factors such as NF-kappaB and HIF-1alpha.
由于氧化还原稳态改变导致的氧化应激逐渐增加，似乎是生理和病理生理过程中调节基因转录的标志之一。活性氧（ROS）和活性氮（RNS）作为信号信使，参与炎症过程的发展和持续，而炎症过程通常与氧化应激状态相关，且涉及基因调控。通过对ROS/RNS敏感的调节转录因子改变基因表达模式，是决定细胞对氧化/氧化还原状态反应机制的关键组成部分。直接受活性物质和促炎信号影响的转录因子包括核因子-κB（NF-κB）和缺氧诱导因子-1α（HIF-1α）。在此，我描述细胞内氧化/氧化还原控制机制的基本组成部分，以及它对诸如NF-κB和HIF-1α等氧和氧化还原敏感转录因子的关键调控。
