Division of Cardiovascular Surgery of Peter Munk Cardiac Centre, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada.
J Thorac Cardiovasc Surg. 2010 Dec;140(6 Suppl):S14-9; discussion S45-51. doi: 10.1016/j.jtcvs.2010.07.041.
This study was undertaken to examine clinical and echocardiographic outcomes of aortic valve-sparing operations to treat aortic root aneurysms.
From May 1988 to December 2007, a total of 228 patients underwent reimplantation of the aortic valve, and 61 underwent remodeling of the aortic root. Patients were followed up prospectively and had echocardiographic evaluation of valve function. Mean follow-up was 7.28 ± 4.33 years.
There were 5 operative and 26 late deaths. Survival at 12 years was 82.9 ± 3.7% and similar between types of operations. Age and aortic dissection were independent predictors of mortality. Seven patients have had reoperations on the aortic valve: 6 for aortic insufficiency and 1 for endocarditis. Five of these patients had undergone remodeling of the aortic root. Freedoms from reoperation at 12 years were 94.3% ± 2.6% among all patients, 90.4% ± 4.7% after remodeling, and 97.4% ± 2.2% after reimplantation (P = .09). Postoperatively, moderate aortic insufficiency developed in 14 patients (8 remodeling and 6 reimplantation) and severe aortic insufficiency in 5 (3 remodeling and 2 reimplantation). The remaining patients had mild, trace, or no aortic insufficiency. Freedoms from moderate or severe aortic insufficiency at 12 years were 86.8% ± 3.8% among all patients, 82.6% ± 6.2% after remodeling, and 91.0% ± 3.8% after reimplantation (P = .035). Only age-by 5-year increments-was an independent predictor of postoperative aortic insufficiency.
Aortic valve-sparing operations provide excellent patient survival and stable aortic valve function, particularly after reimplantation of the aortic valve.
本研究旨在探讨保留主动脉瓣手术治疗主动脉根部瘤的临床和超声心动图结果。
1988 年 5 月至 2007 年 12 月,共 228 例患者接受了主动脉瓣再植入术,61 例患者接受了主动脉根部重建术。患者进行前瞻性随访,并进行瓣膜功能的超声心动图评估。平均随访时间为 7.28±4.33 年。
手术死亡 5 例,晚期死亡 26 例。12 年生存率为 82.9±3.7%,两种手术类型的生存率相似。年龄和主动脉夹层是死亡的独立预测因素。7 例患者行主动脉瓣再次手术:6 例为主动脉瓣关闭不全,1 例为感染性心内膜炎。其中 5 例患者行主动脉根部重建术。所有患者 12 年免于再次手术的比例为 94.3%±2.6%,行主动脉根部重建术的患者为 90.4%±4.7%,行主动脉瓣再植入术的患者为 97.4%±2.2%(P=0.09)。术后 14 例(8 例行主动脉根部重建术,6 例行主动脉瓣再植入术)患者出现中度主动脉瓣关闭不全,5 例(3 例行主动脉根部重建术,2 例行主动脉瓣再植入术)患者出现重度主动脉瓣关闭不全。其余患者为轻度、微量或无主动脉瓣关闭不全。所有患者 12 年免于中度或重度主动脉瓣关闭不全的比例为 86.8%±3.8%,行主动脉根部重建术的患者为 82.6%±6.2%,行主动脉瓣再植入术的患者为 91.0%±3.8%(P=0.035)。只有年龄(每 5 岁为一个等级)是术后主动脉瓣关闭不全的独立预测因素。
保留主动脉瓣手术可提供良好的患者生存率和稳定的主动脉瓣功能,尤其是主动脉瓣再植入术。