Murray Alex J, Rogers Jack C, Katshu Mohammad Zia Ul Haq, Liddle Peter F, Upthegrove Rachel
Institute for Mental Health, University of Birmingham, Birmingham, United Kingdom.
Institute of Mental Health, Division of Mental Health and Neurosciences University of Nottingham, Nottingham, United Kingdom.
Front Psychiatry. 2021 Jul 22;12:703452. doi: 10.3389/fpsyt.2021.703452. eCollection 2021.
Schizophrenia is associated with increased levels of oxidative stress, as reflected by an increase in the concentrations of damaging reactive species and a reduction in anti-oxidant defences to combat them. Evidence has suggested that whilst not the likely primary cause of schizophrenia, increased oxidative stress may contribute to declining course and poor outcomes associated with schizophrenia. Here we discuss how oxidative stress may be implicated in the aetiology of schizophrenia and examine how current understanding relates associations with symptoms, potentially lipid peroxidation induced neuronal damage. We argue that oxidative stress may be a good target for future pharmacotherapy in schizophrenia and suggest a multi-step model of illness progression with oxidative stress involved at each stage.
精神分裂症与氧化应激水平升高有关，这表现为具有损害性的活性物质浓度增加以及对抗这些物质的抗氧化防御能力下降。有证据表明，虽然氧化应激不太可能是精神分裂症的主要病因，但它可能导致精神分裂症病程恶化和预后不良。在此，我们讨论氧化应激可能如何与精神分裂症的病因相关，并研究目前的认识如何将其与症状联系起来，这可能涉及脂质过氧化诱导的神经元损伤。我们认为氧化应激可能是未来精神分裂症药物治疗的一个良好靶点，并提出了一个疾病进展的多步骤模型，其中氧化应激在每个阶段都有涉及。
