Laboratory of Radioecology and Ecotoxicology, IRSN (Institute for Radiological protection and Nuclear Safety), DEI/SECRE/LRE, Cadarache, Bat 186, BP 3, 13115 St-Paul-Lez-Durance cedex, France.
Environ Pollut. 2011 Feb;159(2):495-502. doi: 10.1016/j.envpol.2010.10.013. Epub 2010 Nov 18.
Because of its toxicity and its ubiquity within aquatic compartments, uranium (U) represents a significant hazard to aquatic species such as fish. In a previous study, we investigated some biological responses in zebrafish either exposed to depleted or to enriched U (i.e., to different radiological activities). However, results required further experiments to better understand biological responses. Moreover, we failed to clearly demonstrate a significant relationship between biological effects and U radiological activity. We therefore chose to herein examine U bioaccumulation and induced effects in zebrafish according to a chemical dose-response approach. Results showed that U is highly bioconcentrated in fish, according to a time- and concentration-dependent model. Additionally, hepatic antioxidant defenses, red blood cells DNA integrity and brain acetylcholinesterase activity were found to be significantly altered. Generally, the higher the U concentration, the sooner and/or the greater the effect, suggesting a close relationship between accumulation and effect.
由于铀的毒性及其在水生环境中的普遍性，它对鱼类等水生物种构成了重大危害。在之前的研究中，我们研究了斑马鱼暴露于贫铀或富铀（即不同放射性活度）时的一些生物反应。然而，结果需要进一步的实验来更好地理解生物反应。此外，我们未能清楚地证明生物效应与铀放射性活度之间存在显著关系。因此，我们选择在此根据化学剂量-反应方法检查铀在斑马鱼中的生物积累和诱导效应。结果表明，铀在鱼类中的生物浓缩度很高，符合时间和浓度依赖模型。此外，还发现肝抗氧化防御、红细胞 DNA 完整性和脑乙酰胆碱酯酶活性发生了显著变化。一般来说，铀浓度越高，作用发生得越早和/或越大，这表明积累与效应之间存在密切关系。
