Wayne State University, Detroit, MI 48202, USA.
Eur J Oncol Nurs. 2011 Sep;15(4):318-24. doi: 10.1016/j.ejon.2010.10.003. Epub 2010 Nov 18.
Fatigue and disrupted sleep often coexist and both are prominent clinical problems in cancer affecting quality of life. Disrupted sleep patterns are likely related to cancer-related fatigue. The relationship needs further investigation. This study aimed to characterize and compare disrupted sleep patterns in fatigued breast cancer patients receiving chemotherapy with postmenopausal women without a history of cancer. Anxiety levels were also examined.
Data for this secondary analysis came from two studies. Global sleep quality and state anxiety were self-reported by 30 fatigued female breast cancer chemotherapy outpatients and 32 non-cancer postmenopausal women using Pittsburgh Sleep Quality Index (PSQI) and State-Trait Anxiety Inventory, respectively.
Fatigued breast cancer patients showed significant sleep difficulties, characterized by prolonged sleep onset latency (M=54.3, SD=49.2 min) and frequent nighttime awakenings, despite 40% of the patients using sleep medications three or more times a week. Compared to the non-cancer comparison group, fatigued patients reported significantly longer sleep latency (p=0.041), more use of sleep medications (p=0.006), and higher total PSQI scores (p=0.005). State anxiety levels did not differ between the two groups (p=0.88).
Sleep is disrupted in fatigued breast cancer women undergoing chemotherapy. Nearly all fatigued patients (97%) had trouble sleeping (global PSQI scores>5), indicating significant difficulties in overall sleep quality among those patients. Knowledge of the nature of sleep disruption among cancer patients may contribute to CRF symptom management leading to tailored interventions designed to improve sleep quality in cancer patients thereby managing fatigue and improving quality of life.
疲劳和睡眠紊乱常常同时存在，且都是癌症患者中突出的临床问题，影响生活质量。睡眠模式紊乱可能与癌症相关性疲劳有关。需要进一步研究这种关系。本研究旨在描述和比较正在接受化疗的疲劳乳腺癌患者与无癌症病史的绝经后女性的睡眠紊乱模式，并检查焦虑水平。
本二次分析的数据来自两项研究。30 名疲劳的女性乳腺癌化疗门诊患者和 32 名无癌症的绝经后女性使用匹兹堡睡眠质量指数（PSQI）和状态特质焦虑量表（分别报告总体睡眠质量和状态焦虑。
疲劳的乳腺癌患者表现出明显的睡眠困难，表现为入睡潜伏期延长（M=54.3，SD=49.2 分钟）和夜间频繁醒来，尽管 40%的患者每周使用睡眠药物三或更多次。与非癌症对照组相比，疲劳患者报告的入睡潜伏期明显更长（p=0.041），使用睡眠药物的次数更多（p=0.006），PSQI 总分更高（p=0.005）。两组之间的状态焦虑水平没有差异（p=0.88）。
正在接受化疗的疲劳乳腺癌女性的睡眠受到干扰。近所有疲劳患者（97%）都有睡眠困难（PSQI 总分>5），表明这些患者的整体睡眠质量存在明显困难。了解癌症患者睡眠紊乱的性质可能有助于管理 CRF 症状，从而制定有针对性的干预措施，改善癌症患者的睡眠质量，从而管理疲劳，提高生活质量。
