Schlosser Bethanee J, Pirigyi Megan, Mirowski Ginat W
Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Otolaryngol Clin North Am. 2011 Feb;44(1):183-203, vii. doi: 10.1016/j.otc.2010.09.007.
Oral manifestations of hematologic and nutritional deficiencies can affect the mucous membranes, teeth, periodontal tissues, salivary glands, and perioral skin. This article reviews common oral manifestations of hematologic conditions starting with disorders of the white blood cells including cyclic hematopoiesis (cyclic neutropenia), leukemias, lymphomas, plasma cell dyscrasias, and mast cell disorders; this is followed by a discussion of the impact of red blood cell disorders including anemias and less common red blood cell dyscrasias (sickle cell disease, hemochromatosis, and congenital erythropoietic porphyria) as well as thrombocytopenia. Several nutritional deficiencies exhibit oral manifestations. The authors specifically discuss the impact of water-soluble vitamins (B2, B3, B6, B9, B12, and C), fat-soluble vitamins (A, D, and K) and the eating disorders anorexia nervosa and bulimia nervosa on the oral mucosa.
血液学和营养缺乏的口腔表现可影响黏膜、牙齿、牙周组织、唾液腺和口周皮肤。本文回顾血液学疾病的常见口腔表现，首先是白细胞疾病，包括周期性造血（周期性中性粒细胞减少症）、白血病、淋巴瘤、浆细胞异常增生症和肥大细胞疾病；接着讨论红细胞疾病的影响，包括贫血和较罕见的红细胞发育异常（镰状细胞病、血色素沉着症和先天性红细胞生成性卟啉症）以及血小板减少症。几种营养缺乏也有口腔表现。作者特别讨论了水溶性维生素（维生素B2、B3、B6、B9、B12和C）、脂溶性维生素（维生素A、D和K）以及饮食失调症神经性厌食症和神经性贪食症对口腔黏膜的影响。
