Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA.
Clin Geriatr Med. 2011 Feb;27(1):27-37. doi: 10.1016/j.cger.2010.08.006.
In developing and validating the concept of frailty as a geriatric syndrome, it has been necessary to distinguish the clinical expression of frailty from normal age-related changes and other age-related disease pathologies. A framework for excluding potentially confounding disease and a working clinical tool to diagnose frailty have been provided. The associations between frailty and other pathophysiologies has also been shown. However, investigating the underlying biologic basis for the geriatric syndrome of frailty by studying basic homeostatic pathways and mechanisms has not proceeded at the same rate. The following article provides an overview of the homeostatic pathways emphasized in research on aging and explains how this science may help to stimulate frailty research.
在提出和验证衰弱作为一种老年综合征的概念时，有必要将衰弱的临床表现与正常的年龄相关变化和其他与年龄相关的疾病病理区分开来。为此提供了一个排除潜在混杂疾病的框架和一种用于诊断衰弱的临床实用工具。还表明了衰弱与其他病理生理学之间的关联。然而，通过研究基本的体内平衡途径和机制来研究老年综合征衰弱的潜在生物学基础的进展并不快。本文概述了衰老研究中强调的体内平衡途径，并解释了这些科学如何有助于激发衰弱研究。
