Department of Developmental and Molecular Biology and Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Curr Opin Cell Biol. 2011 Apr;23(2):184-9. doi: 10.1016/j.ceb.2010.10.009. Epub 2010 Nov 18.
Chaperone-mediated autophagy is a selective mechanism for degradation of soluble cytosolic proteins in lysosomes that distinguishes itself from other autophagic pathways by the selectivity with which CMA substrates are targeted for degradation. The recent molecular dissection of this autophagic pathway and the development of experimental models with compromised CMA have unveiled the important contribution of this pathway to protein quality control. In fact, CMA activation seems to be a common mechanism of cellular defense against proteotoxicity.
伴侣蛋白介导的自噬是溶酶体中降解可溶性胞质蛋白的一种选择性机制，其通过 CMA 底物被选择性降解来区分于其他自噬途径。最近对这条自噬途径的分子剖析以及建立了 CMA 受损的实验模型，揭示了该途径对蛋白质质量控制的重要贡献。事实上，CMA 的激活似乎是细胞抵御蛋白毒性的一种常见机制。
