King's College London and Guy's and St Thomas' NHS Foundation Trust, United Kingdom.
Eur J Cancer. 2011 Mar;47(4):536-44. doi: 10.1016/j.ejca.2010.10.015. Epub 2010 Nov 18.
The organisation of cancer research is critical to its overall creativity and productivity. Cancer centres are a major organisational structure for this research, however, little is known about their effect on research or how national policy-making intersects with this complex policy nexus. This study of the evolution of United Kingdom cancer centres (UKCC), part of a wider European and United States programme, uses a bibliometric analysis of research activity prior to the creation of the NCRI and after its formation (1995-2004/5). In terms of critical research mass UKCC are very heterogeneous with a fourfold difference between the top and bottom quintiles. UK centres published just over one eighth of the total UKCC in 1995 but almost a quarter by 2004. This centrification occurred in the absence of any national strategy. Overall these centres conduct more fundamental (laboratory-based) research than that being conducted in the wider network but this hides major heterogeneity. UKCC collaborate with European investigators in 5-28% of all their outputs and with USA the range is between 6% and 21%. We have also derived new measures of research impact on clinical management and the general public as well as the impact of national policy on research assessment for certain types of cancer research.
癌症研究的组织对于其整体的创新性和生产力至关重要。癌症中心是该研究的主要组织结构，但对于它们对研究的影响知之甚少，也不清楚国家政策制定如何与这一复杂的政策关系交织在一起。这项对英国癌症中心（UKCC）演变的研究是一个更广泛的欧洲和美国项目的一部分，使用了在 NCRI 成立之前和之后（1995-2004/5）的研究活动的文献计量分析。就关键研究质量而言，UKCC 非常多样化，最高和最低五分位数之间相差四倍。1995 年，英国中心发表的论文仅略多于 UKCC 的八分之一，但到 2004 年，这一比例接近四分之一。这种集中化是在没有任何国家战略的情况下发生的。总体而言，这些中心进行的基础研究（基于实验室的研究）多于更广泛网络中的研究，但这掩盖了重大的异质性。UKCC 在其所有产出的 5-28%与欧洲调查人员合作，与美国的合作范围在 6%到 21%之间。我们还得出了一些新的衡量标准，用于衡量对临床管理和公众的研究影响，以及国家政策对某些类型的癌症研究评估的影响。
