Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330, Ankara, Turkey.
J Ethnopharmacol. 2011 Feb 16;133(3):1027-32. doi: 10.1016/j.jep.2010.11.036. Epub 2010 Nov 19.
Female flowers inflorescence of Typha species including Typha domingensis Pers. are used externally for burns and wound healing in Turkish folk medicine. In order to verify the folkloric assertion, the female and male flowers inflorescences were individually submitted to in vivo wound models.
Ointment formulations prepared directly either from the male or female flowers inflorescences of Typha domingensis in 5% and 10% concentrations were submitted to activity testing. After that, female flowers inflorescence was further submitted to successive extractions with solvents in increasing polarity; i.e., n-hexane, chloroform, methanol and water and the wound healing activity of each extract was investigated. The linear incision and circular excision wound models were used for the evaluation of the healing potential of the test materials in rats and mice. Tissue sections were also evaluated by histopathological techniques.
Remarkable wound healing activity was observed only for the female flowers inflorescence at 5% concentration in ointment base and its methanolic and aqueous extracts. The wound healing effect was found comparable to that of reference ointment Madecassol(®). The results of histopathological evaluation supported the outcome of both linear incision and circular excision wound models.
The experimental study revealed that the female flowers inflorescence of Typha domingensis displayed notable wound healing activity in mice and rats, at the models tested.
包括 Typha domingensis Pers. 在内的香蒲属植物的雌花花序在土耳其民间医学中被用于烧伤和伤口愈合的外部治疗。为了验证民间传说，单独将雄花和雌花花序用于体内伤口模型。
直接从 Typha domingensis 的雄花或雌花花序制备的 5%和 10%浓度的软膏制剂分别进行了活性测试。之后，进一步对雌花花序进行连续的溶剂提取，极性依次增加，即正己烷、氯仿、甲醇和水，并研究了每种提取物的伤口愈合活性。线性切口和圆形切除伤口模型用于评估测试材料在大鼠和小鼠中的愈合潜力。还通过组织病理学技术评估组织切片。
仅在软膏基质和其甲醇和水提取物中，以 5%浓度的雌花花序观察到显著的伤口愈合活性。愈合效果与参比软膏 Madecassol(®)相当。组织病理学评估的结果支持线性切口和圆形切除伤口模型的结果。
实验研究表明，在所测试的模型中，Typha domingensis 的雌花花序显示出显著的伤口愈合活性。
