嗜酸性粒细胞增多的急性粒单核细胞白血病中单核细胞、嗜酸性粒细胞和嗜碱性粒细胞系肿瘤性受累的证据。

Evidence for the neoplastic involvement of monocytic, eosinophilic and basophilic lineages in acute myelomonocytic leukemia with eosinophilia.

作者信息

Yanagisawa K, Fukuoka T, Fujita S

机构信息

First Department of Internal Medicine, School of Medicine, Ehime University, Japan.

出版信息

Acta Haematol. 1990;83(3):145-8. doi: 10.1159/000205192.

DOI:10.1159/000205192

PMID:2109454

Abstract

To investigate the origin of cells observed in acute myelomonocytic leukemia with eosinophilia (M4E0), we carried out morphological and cytogenetic studies of colonies derived from leukemic precursors. Marrow cells from a patient with M4E0 at second relapse revealed an abnormal karyotype; 47,XY, +8, inv(16)(p13q22), 17p-. Cytogenetic studies of leukemic colonies showed the same karyotypic abnormality. The primary and secondary colonies consisted of monocytes, eosinophils and basophils. These results indicated that the neoplastic process in this patient originated in a stem cell capable of differentiation into at least monocytes, eosinophils and basophils.

摘要

为了研究伴有嗜酸性粒细胞增多的急性粒单核细胞白血病（M4E0）中所观察到的细胞起源，我们对白血病前体细胞来源的集落进行了形态学和细胞遗传学研究。一名处于第二次复发期的M4E0患者的骨髓细胞显示出异常核型；47，XY，+8，inv(16)(p13q22)，17p-。白血病集落的细胞遗传学研究显示出相同的核型异常。初级和次级集落均由单核细胞、嗜酸性粒细胞和嗜碱性粒细胞组成。这些结果表明，该患者的肿瘤形成过程起源于一种能够分化为至少单核细胞、嗜酸性粒细胞和嗜碱性粒细胞的干细胞。