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Trisomy 21 as the sole clonal aberration in a patient with acute myelomonocytic leukemia with abnormal bone marrow eosinophils and extramedullary involvement.

作者信息

Dengler R, Walther J U, Emmerich B

机构信息

Abteilung für Hämatologie und Onkologie, Universität, München, Germany.

出版信息

Ann Hematol. 1994 Feb;68(2):93-5. doi: 10.1007/BF01715140.

DOI:10.1007/BF01715140
PMID:8148422
Abstract

We describe a 30-year-old acute myelomonocytic leukemia patient with abnormal bone marrow eosinophils (AML FAB subtype M4Eo) with extensive extramedullary involvement and, in the abscence of an aberration involving chromosome 16, clonal trisomy 21 in the leukemic blast cells.

摘要

相似文献

1
Trisomy 21 as the sole clonal aberration in a patient with acute myelomonocytic leukemia with abnormal bone marrow eosinophils and extramedullary involvement.
Ann Hematol. 1994 Feb;68(2):93-5. doi: 10.1007/BF01715140.
2
[Acute myelomonocytic leukemia with eosinophils. Apropos of a case with a cytogenetic analysis and nosologic discussion].[伴有嗜酸性粒细胞的急性粒单核细胞白血病。关于一例进行细胞遗传学分析及疾病分类学讨论的病例]
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Acute lysis pneumopathy after chemotherapy for acute myelomonocytic leukemia with abnormal marrow eosinophils.急性骨髓单核细胞白血病伴骨髓嗜酸性粒细胞异常化疗后急性溶解肺病变
Cancer. 1992 Mar 15;69(6):1356-61. doi: 10.1002/1097-0142(19920315)69:6<1356::aid-cncr2820690609>3.0.co;2-b.
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The abnormal eosinophils are part of the leukemic cell population in acute myelomonocytic leukemia with abnormal eosinophils (AML M4Eo) and carry the pericentric inversion 16: a combination of May-Grünwald-Giemsa staining and fluorescence in situ hybridization.异常嗜酸性粒细胞是伴有异常嗜酸性粒细胞的急性粒单核细胞白血病（AML M4Eo）白血病细胞群的一部分，并携带16号染色体臂间倒位：采用May-Grünwald-Giemsa染色和荧光原位杂交相结合的方法。
Blood. 1996 Mar 15;87(6):2459-63.
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Evidence for the neoplastic involvement of monocytic, eosinophilic and basophilic lineages in acute myelomonocytic leukemia with eosinophilia.嗜酸性粒细胞增多的急性粒单核细胞白血病中单核细胞、嗜酸性粒细胞和嗜碱性粒细胞系肿瘤性受累的证据。
Acta Haematol. 1990;83(3):145-8. doi: 10.1159/000205192.
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Involvement of erythrocytic and granulomonocytic lineages by trisomy 11 in two cases of acute myelomonocytic leukemia with trilineage myelodysplasia. An interphase cytogenetic study.11号染色体三体累及红细胞系和粒单核细胞系：两例伴有三系骨髓发育异常的急性粒单核细胞白血病的研究。间期细胞遗传学研究
Cancer Genet Cytogenet. 1994 Oct;77(1):33-8. doi: 10.1016/0165-4608(94)90145-7.
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M4Eo--eosinophilic variant of acute myelomonocytic leukaemia.
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Trisomy 21 in acute myeloid leukemia.
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Granulocytic sarcomas of small intestine and brain are associated with acute myelomonocytic leukaemia with abnormal eosinophils and inversion of chromosome 16.小肠和脑的粒细胞肉瘤与伴有异常嗜酸性粒细胞和16号染色体倒位的急性粒单核细胞白血病相关。
Leuk Lymphoma. 1992 Nov;8(4-5):409-13. doi: 10.3109/10428199209051022.
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Myelodysplastic syndrome preceding acute myelomonocytic leukemia with dysplastic marrow eosinophilia and inv(16).伴有发育异常性骨髓嗜酸性粒细胞增多和inv(16)的急性粒单核细胞白血病之前的骨髓增生异常综合征
Acta Haematol. 1989;82(3):161-4. doi: 10.1159/000205368.

引用本文的文献

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Biological and clinical features of trisomy 21 in adult patients with acute myeloid leukemia.成人急性髓系白血病患者 21 三体的生物学和临床特征。
Clin Lymphoma Myeloma Leuk. 2013 Sep;13 Suppl 2(0 2):S276-81. doi: 10.1016/j.clml.2013.05.020. Epub 2013 Aug 19.

本文引用的文献

1
Clinical aspects of acute myeloid leukemias of the FAB types M3 and M4Eo. The AML Cooperative Group.FAB分型M3和M4Eo急性髓系白血病的临床特征。AML协作组。
Ann Hematol. 1993 Apr;66(4):165-70. doi: 10.1007/BF01703230.
2
Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia.急性髓系白血病中转录因子CBFβ/PEBP2β与肌球蛋白重链之间的融合
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Cytogenetic studies on acute myelomonocytic leukaemia (M4) with eosinophilia.伴有嗜酸性粒细胞增多的急性粒单核细胞白血病（M4）的细胞遗传学研究
Leuk Res. 1985;9(2):279-88. doi: 10.1016/0145-2126(85)90090-6.
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Acute myelomonocytic leukemia with abnormal eosinophils and inv(16) or t(16;16) has a favorable prognosis.
Blood. 1986 Dec;68(6):1242-9.
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Trisomy 22--a new abnormality found in acute leukemia characterized by eosinophilia and monocytoid blasts expressing immature differentiation antigens.
Cancer Genet Cytogenet. 1986 Oct;23(2):105-14. doi: 10.1016/0165-4608(86)90410-3.
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Morphologic, immunologic, and cytogenetic (MIC) working classification of the acute myeloid leukemias. Report of the Workshop held in Leuven, Belgium, September 15-17, 1986. Second MIC Cooperative Study Group.
Cancer Genet Cytogenet. 1988 Jan;30(1):1-15.
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Detection of karyotypic abnormalities in most patients with acute nonlymphocytic leukemia by adding ethidium bromide to short-term cultures.通过在短期培养物中添加溴化乙锭来检测大多数急性非淋巴细胞白血病患者的核型异常。
Leuk Res. 1988;12(9):719-29. doi: 10.1016/0145-2126(88)90004-5.
10
Prognostic impact of cytogenetic abnormalities in patients with de novo acute nonlymphocytic leukemia.
Blood. 1989 Jan;73(1):263-70.