1例急性粒单核细胞白血病伴骨髓嗜酸性粒细胞增多和16号染色体倒位患者嗜碱性粒细胞增多。

An increase in basophils in a case of acute myelomonocytic leukaemia associated with marrow eosinophilia and inversion of chromosome 16.

作者信息

Matsuura Y, Sato N, Kimura F, Shimomura S, Yamamoto K, Enomoto Y, Takatani O

机构信息

3rd Department of Internal Medicine, National Defense Medical College, Saitama, Japan.

出版信息

Eur J Haematol. 1987 Nov;39(5):457-61. doi: 10.1111/j.1600-0609.1987.tb01456.x.

DOI:10.1111/j.1600-0609.1987.tb01456.x

PMID:3480240

Abstract

A patient with acute myelomonocytic leukaemia (M4 subtype) with pericentric inversion of chromosome 16, inv(16)(p13q22), and a marked basophilia is described. Results from transmission electron microscopy suggested that the basophils were immature. Clinically, although leukaemic cells had a tendency to infiltrate a number of tissues and organs, such as skin, gingiva, liver and lung, the patient was successfully treated with chemotherapy. The increase in basophils accompanied by marrow eosinophilia may be the result of abnormal differentiation of leukaemic cells that have the capacity to differentiate into both the eosinophilic and basophilic pathways.

摘要

描述了一名患有急性粒单核细胞白血病（M4亚型）的患者，其16号染色体臂间倒位，inv(16)(p13q22)，并有明显的嗜碱性粒细胞增多。透射电子显微镜检查结果表明嗜碱性粒细胞不成熟。临床上，尽管白血病细胞有浸润多种组织和器官的倾向，如皮肤、牙龈、肝脏和肺，但该患者通过化疗成功治愈。嗜碱性粒细胞增多伴骨髓嗜酸性粒细胞增多可能是具有分化为嗜酸性和嗜碱性两条途径能力的白血病细胞异常分化的结果。