Aab Cardiovascular Research Institute, University of Rochester School of Medicine & Dentistry, 601 Elmwood Avenue, Box CVRI, Rochester, New York 14642, USA.
Thromb Res. 2011 May;127(5):387-90. doi: 10.1016/j.thromres.2010.10.019. Epub 2010 Nov 20.
Platelets are dynamic cells with activities that extend beyond thrombosis including an important role in initiating and sustaining vascular inflammation. A role for platelets has been described in many physiologic and pathophysiologic processes such as atherosclerosis, stem cell trafficking, tumor metastasis, and arthritis. Platelet activation at sites of an intact inflamed endothelium contributes to vascular inflammation and vascular wall remodeling. Platelets secrete a wide array of preformed and synthesized inflammatory mediators upon activation that can exert significant local and systemic effects. This review will focus on the role of platelet derived mediators in vascular inflammation and vascular wall remodeling.
血小板是具有多种活性的动态细胞，其功能不仅限于血栓形成，还包括在启动和维持血管炎症方面发挥重要作用。血小板在许多生理和病理生理过程中都具有作用，如动脉粥样硬化、干细胞迁移、肿瘤转移和关节炎。在完整炎症内皮细胞的部位，血小板的激活有助于血管炎症和血管壁重塑。血小板在激活时会分泌广泛的预先形成和合成的炎症介质，这些介质可以产生显著的局部和全身效应。本文将重点讨论血小板衍生介质在血管炎症和血管壁重塑中的作用。
