Epidemiology Research Center, Marshfield Clinic Research Foundation, Marshfield, WI 54449, USA.
Vaccine. 2011 Jan 10;29(3):387-90. doi: 10.1016/j.vaccine.2010.10.082. Epub 2010 Nov 21.
Annual evaluation of influenza vaccine effectiveness (VE) is needed to assess ongoing impact of immunization efforts in the setting of antigenic drift and periodic vaccine reformulation. Optimal methodology for determining VE remains unclear. We compared influenza VE generated from prospective enrollment and rRT-PCR testing (active surveillance group) with VE based on clinician-ordered diagnostic tests (clinical testing group) in a defined population over four seasons. VE was calculated as (1 - adjusted OR) for vaccination in cases vs. test-negative controls. VE based on clinical testing underestimated VE based on active surveillance and testing with rRT-PCR by 5-33% depending on season.
年度评估流感疫苗效果（VE）对于评估在抗原漂移和定期疫苗配方改革背景下免疫接种工作的持续影响非常重要。确定 VE 的最佳方法仍不清楚。我们在四个季节内，将前瞻性登记和 rRT-PCR 检测（主动监测组）产生的流感 VE 与基于临床医生开具的诊断检测的 VE（临床检测组）进行了比较，这是在一个特定人群中进行的。在病例与阴性对照的检测中，疫苗接种的 VE 计算为（1-调整后的 OR）。基于临床检测的 VE 比基于主动监测和 rRT-PCR 检测的 VE 低估了 5-33%，具体取决于季节。
