Graduate Institute of Microbiology and Public Health, College of Veterinary Medicine, National Chung-Hsing University, Taichung 401, Taiwan.
Vaccine. 2011 Jan 17;29(4):617-23. doi: 10.1016/j.vaccine.2010.11.016. Epub 2010 Nov 21.
The serological response of the current 2009 H1N1 pandemic influenza monovalent vaccine in children exhibiting high baseline seropositive rate was evaluated though a community-based household study. Seroprotection rate of >90% and seroconversion rate of >50% were observed in children one month after receiving the pandemic vaccine. Among children with low baseline antibody titer, a significant lower seroconversion rate (55%) was observed in children who received seasonal trivalent inactivated vaccine (TIV) prior to pandemic vaccine, when compared with those receiving the pandemic vaccine only (86%). Persistence of antibody against the pandemic influenza virus was observed 6 months after vaccination in >80% of children presenting seroprotective antibody levels.
通过一项基于社区的家庭研究，评估了在基线血清阳性率较高的儿童中，当前的 2009 年 H1N1 大流行流感单价疫苗的血清学反应。在接种大流行疫苗一个月后，观察到 >90%的儿童具有血清保护率和 >50%的血清转化率。在基线抗体滴度较低的儿童中，与仅接种大流行疫苗的儿童（86%）相比，先前接种季节性三价灭活疫苗（TIV）的儿童的血清转化率（55%）显著较低。在接种疫苗后 6 个月时，>80%呈现血清保护抗体水平的儿童中观察到针对大流行流感病毒的抗体持续存在。
