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儿童感染病毒与接种疫苗对 2009 年甲型 H1N1 流感病毒免疫反应的比较。

Comparison of immune response by virus infection and vaccination to 2009 pandemic influenza A/H1N1 in children.

机构信息

Department of Pediatrics, Dongguk University Ilsan Hospital, Goyang, Korea.

出版信息

J Korean Med Sci. 2013 Feb;28(2):274-9. doi: 10.3346/jkms.2013.28.2.274. Epub 2013 Jan 29.

DOI:10.3346/jkms.2013.28.2.274
PMID:23399558
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3565140/
Abstract

We aimed to compare the immune response induced by natural infection with 2009 pandemic influenza A/H1N1 (pH1N1) virus and by monovalent pH1N1 vaccination in children and adolescents. This cross-sectional clinical study was conducted at 3 hospitals in Korea from February to May 2010. A total of 266 healthy subjects aged from 6 months to 18 yr were tested for the presence of the antibody against pH1N1 using hemagglutination inhibition (HI) test. Information about pH1N1 vaccination and laboratory-confirmed pH1N1 infection history was obtained. The overall rate of HI titers of ≥ 1:40 against pH1N1 was 38.7%, and the geometric mean titer (GMT) was 20.5. Immunogenicity of pH1N1 vaccination only was reflected by a 41.1% of seroprotection rate and a GMT of 22.5. Immunogenicity of natural infection only was reflected by a 61.0% of seroprotection rate and a GMT of 40.0. GMT was significantly higher in the subjects of natural infection group than in the subjects of pH1N1 vaccination group (P < 0.001). The immune responses induced by natural pH1N1 infection exceed those induced by pH1N1 vaccinations.

摘要

我们旨在比较儿童和青少年中由 2009 年甲型 H1N1（pH1N1）流感病毒自然感染和单价 pH1N1 疫苗接种引起的免疫反应。这是一项在韩国 3 家医院进行的横断面临床研究，时间为 2010 年 2 月至 5 月。共有 266 名年龄在 6 个月至 18 岁的健康受试者接受了血凝抑制（HI）试验，以检测针对 pH1N1 的抗体。获取了 pH1N1 疫苗接种和实验室确诊的 pH1N1 感染史信息。针对 pH1N1 的 HI 滴度≥1:40 的总体阳性率为 38.7%，几何平均滴度（GMT）为 20.5。仅 pH1N1 疫苗接种的免疫原性反映为血清保护率为 41.1%，GMT 为 22.5。仅自然感染的免疫原性反映为血清保护率为 61.0%，GMT 为 40.0。自然感染组的 GMT 明显高于 pH1N1 疫苗接种组（P<0.001）。由自然 pH1N1 感染引起的免疫反应超过 pH1N1 疫苗接种引起的免疫反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922e/3565140/7637f5e15cd8/jkms-28-274-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922e/3565140/9929b0e48827/jkms-28-274-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922e/3565140/e28851467937/jkms-28-274-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922e/3565140/7637f5e15cd8/jkms-28-274-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922e/3565140/9929b0e48827/jkms-28-274-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922e/3565140/e28851467937/jkms-28-274-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922e/3565140/7637f5e15cd8/jkms-28-274-g003.jpg

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