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营养与胃肠胰神经内分泌肿瘤。

Nutrition and gastroenteropancreatic neuroendocrine tumors.

机构信息

UCLA Center for Excellence in Pancreatic Diseases, Los Angeles, CA 90095-1786, USA.

出版信息

Endocrinol Metab Clin North Am. 2010 Dec;39(4):827-37. doi: 10.1016/j.ecl.2010.08.003.

Abstract

Gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) are relatively rare neoplasms that characteristically synthesize and secrete an excess of a variety of regulatory peptides, hormones, and neuroamines, which regulate gut and pancreatic function. This excess can lead to distinct clinical syndromes. Therapeutic strategies include surgery, radiofrequency ablation, chemotherapy, chemoembolization, and biotherapy using somatostatin analogs. The clinical syndromes and the various management strategies can lead to altered gut and pancreatic function with nutritional consequences. Diet and nutritional management is critical for GEP NET patients and is the focus of this article.

摘要

胃肠胰神经内分泌肿瘤(GEP-NETs)是相对罕见的肿瘤,其特征是合成和分泌过量的各种调节肽、激素和神经胺,这些物质调节肠道和胰腺功能。这种过量会导致明显的临床综合征。治疗策略包括手术、射频消融、化疗、化疗栓塞和使用生长抑素类似物的生物治疗。临床综合征和各种管理策略会导致肠道和胰腺功能改变,从而产生营养后果。饮食和营养管理对 GEP-NET 患者至关重要,也是本文的重点。

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