Assembling ligands in situ using bioorthogonal boronate ester synthesis.
作者信息
Shin Sung Bin Y, Almeida Ramiro D, Gerona-Navarro Guillermo, Bracken Clay, Jaffrey Samie R
机构信息
Department of Pharmacology, Weill Medical College, Cornell University, New York, NY 10065, USA.
出版信息
Chem Biol. 2010 Nov 24;17(11):1171-6. doi: 10.1016/j.chembiol.2010.09.008.
Abstract
Many molecules that could manipulate cellular function are not practical due to their large size and concomitant undesirable pharmocokinetic properties. Here, we describe a bioorthogonal, highly stable boronate ester (HiSBE) synthesis and use this reaction to synthesize a biologically active molecule from smaller precursors in a physiological context. The rapid rate of HiSBE synthesis suggests that it may be useful for assembling a wide variety of biologically active molecules in physiological solutions.
摘要
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