革兰氏阴性菌的八种β-内酰胺酶的特性分析
Characterization of eight beta-lactamases of Gram-negative bacteria.
作者信息
Sawai T, Kanno M, Tsukamoto K
出版信息
J Bacteriol. 1982 Nov;152(2):567-71. doi: 10.1128/jb.152.2.567-571.1982.
Abstract
Eight kinds of beta-lactamases produced by gram-negative bacteria were characterized by the following properties: molecular weight, isoelectric point, pH optimum, molecular activity, immunochemical reactivity, and kinetic parameters with respect to twelve kinds of common beta-lactam antibiotics. These beta-lactamases included two types of penicillinases mediated by R plasmids and six kinds of species-specific cephalosporinases. To determine a reliable value of the kinetic parameter, Km, we introduced a continuous and acidimetric assay method of beta-lactamase activity with a pH stat.
摘要
革兰氏阴性菌产生的八种β-内酰胺酶具有以下特性：分子量、等电点、最适pH值、分子活性、免疫化学反应性以及针对十二种常见β-内酰胺抗生素的动力学参数。这些β-内酰胺酶包括由R质粒介导的两种青霉素酶和六种种属特异性头孢菌素酶。为了确定动力学参数Km的可靠值，我们引入了一种使用pH计的β-内酰胺酶活性连续酸碱滴定测定法。
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