淋病奈瑟菌对头孢噻肟和头孢唑肟的敏感性。
Susceptibility of Neisseria gonorrhoeae to cefotaxime and ceftizoxime.
作者信息
Sng E H, Rajan V S, Pang R, Yeo K L
出版信息
Br J Vener Dis. 1981 Jun;57(3):162-4. doi: 10.1136/sti.57.3.162.
Abstract
Two hundred and thirty-nine penicillinase-positive and 240 penicillinase-negative strains of Neisseria gonorrhoeae were tested for their susceptibility to cefotaxime. All were susceptible to cefotaxime at a concentration of 0.062 micrograms/ml. Penicillinase-negative strains were less susceptible than penicillinase-positive strains. This is attributed to the use of prophylactic antibiotics by prostitutes, which has led to the selection of less susceptible penicillinase-negative strains but has not affected the susceptibility of penicillinase-positive strains. The minimum inhibitory concentrations of cefotaxime showed significant positive correlations with those of penicillin, ampicillin, tetracycline, and kanamycin but had a negative correlation with spectinomycin. The related cephalosporin, ceftizoxime, was found to be as effective as cefotaxime against penicillinase-positive and penicillinase-negative gonococci.
摘要
对239株青霉素酶阳性和240株青霉素酶阴性淋病奈瑟菌进行了头孢噻肟敏感性测试。所有菌株在浓度为0.062微克/毫升时对头孢噻肟均敏感。青霉素酶阴性菌株比青霉素酶阳性菌株敏感性低。这归因于妓女使用预防性抗生素，导致选择了敏感性较低的青霉素酶阴性菌株，但未影响青霉素酶阳性菌株的敏感性。头孢噻肟的最低抑菌浓度与青霉素、氨苄西林、四环素和卡那霉素的最低抑菌浓度呈显著正相关，但与壮观霉素呈负相关。发现相关头孢菌素头孢唑肟对青霉素酶阳性和青霉素酶阴性淋球菌的效果与头孢噻肟相同。
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本文引用的文献
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HR 756--a new cephalosporin in the treatment of gonorrhoea caused by ordinary and penicillinase-producing strains of Neisseria gonorrhoeae.HR 756——一种用于治疗由普通淋病奈瑟菌菌株和产青霉素酶淋病奈瑟菌菌株引起的淋病的新型头孢菌素。
Br J Vener Dis. 1980 Aug;56(4):255-8. doi: 10.1136/sti.56.4.255.
2
In vitro antimicrobial activity of cefoperazone, cefotaxime, moxalactam (LY127935), azlocillin, mezlocillin, and other beta-lactam antibiotics against Neisseria gonorrhoeae and Haemophilus influenzae, including beta-lactamase-producing strains.头孢哌酮、头孢噻肟、拉氧头孢（LY127935）、阿洛西林、美洛西林及其他β-内酰胺类抗生素对淋病奈瑟菌和流感嗜血杆菌的体外抗菌活性，包括产β-内酰胺酶菌株。
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