Stieglitz T, Huang W, Chen S C, Morley J W, Lovell N H, Suaning G J
Laboratory for Biomedical Microtechnology, Department of Microsystems Engineering-IMTEK and the Bernstein Center Freiburg, University of Freiburg, Germany.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:1796-9. doi: 10.1109/IEMBS.2010.5626394.
Intrinsic signal optical imaging (ISOI) is a technique that enables researchers to relate changes in cortical activity in response to stimuli by measuring changes in hemoglobin oxygenation and local blood volume. As the time course of these changes - local blood volume in particular - is of the order of seconds, the neural activity that initiates these changes is only indirectly acquired in ISOI. To better correlate these events, it is beneficial to simultaneously record both the evoked cortical potentials and ISOI. In this study we present a novel, transparent, recording array that allows the combination of optical imaging with electrical recordings without the use of metal electrodes in the observation field. Pilot data were recorded after visual and electrical stimuli of the eye to prove the concept.
内在信号光学成像（ISOI）是一种技术，它通过测量血红蛋白氧合和局部血容量的变化，使研究人员能够将皮质活动的变化与对刺激的反应联系起来。由于这些变化的时间进程——特别是局部血容量——以秒为单位，在ISOI中引发这些变化的神经活动只是间接获得的。为了更好地关联这些事件，同时记录诱发的皮质电位和ISOI是有益的。在本研究中，我们展示了一种新型的透明记录阵列，该阵列允许在不使用观察区域中的金属电极的情况下将光学成像与电记录相结合。在对眼睛进行视觉和电刺激后记录了初步数据以验证这一概念。
