Ruther Patrick, Holzhammer Tobias, Herwik Stanislav, Rich P Dylan, Dalley Jeffrey W, Paul Oliver, Holtzman Tahl
Department of Microsystems Engineering, University of Freiburg, Germany.
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:2284-7. doi: 10.1109/IEMBS.2011.6090575.
This paper reports on a compact, small-scale neural recording system combining state-of-art silicon-based probe arrays with a light-weight 32-channel wireless head stage. The system is equipped with two- and four-shaft, comb-shaped probe arrays connected to highly flexible ribbon cables enabling a reliable and controlled insertion of probe arrays through the intact dura mater into the medial prefrontal cortex and nucleus accumbens of rats. The in vivo experiments applied the 5-choice serial reaction time task (5-CSRTT) using freely behaving rats in order to understand the neural basis of sustained visual attention and impulsivity. The long-term stability of the system allowed local field potential (LFP) activity to be recorded without a significant decrement in signal quality for up to 28 weeks, and similarly, we were able to follow single unit activity for up to 4 weeks.
本文报道了一种紧凑的小型神经记录系统，该系统将先进的硅基探针阵列与轻量级32通道无线头戴式前置放大器相结合。该系统配备了双轴和四轴梳状探针阵列，这些阵列连接到高度灵活的带状电缆上，能够将探针阵列可靠且可控地通过完整的硬脑膜插入大鼠的内侧前额叶皮质和伏隔核。体内实验采用5选串行反应时任务（5-CSRTT），使用自由活动的大鼠，以了解持续视觉注意力和冲动性的神经基础。该系统的长期稳定性使得能够记录局部场电位（LFP）活动，信号质量在长达28周的时间内没有显著下降，同样，我们能够跟踪单个单元活动长达4周。
