Bai Siwei, Loo Colleen, Dokos Socrates
Graduate School of Biomedical Engineering, Faculty of Engineering, University of New South Wales (UNSW), Australia.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:2069-72. doi: 10.1109/IEMBS.2010.5626333.
Electroconvulsive therapy (ECT) is the most effective treatment for severe depressive disorder, and yet the mechanisms of its therapeutic effects remain largely unknown. A novel computational model is presented in this study to simulate and investigate direct cortical excitation caused by bitemporal electroconvulsive therapy (BT ECT), using a finite element model (FEM) of the human head. The skull was modeled with anisotropic conductivity, with an excitable ionic neural model incorporated into the brain based on the classic Hodgkin-Huxley formulation. Results suggested that this model is able to reproduce direct stimulation of the cortex during the application of ECT.
电休克疗法（ECT）是治疗重度抑郁症最有效的方法，但其治疗效果的机制在很大程度上仍不为人知。本研究提出了一种新型计算模型，以使用人体头部的有限元模型（FEM）来模拟和研究双侧颞部电休克疗法（BT ECT）引起的直接皮层兴奋。颅骨采用各向异性电导率建模，基于经典的霍奇金-赫胥黎公式将可兴奋离子神经模型纳入大脑。结果表明，该模型能够再现ECT应用过程中对皮层的直接刺激。
