Lee Won Hee, Lisanby Sarah H, Laine Andrew F, Peterchev Angel V
Annu Int Conf IEEE Eng Med Biol Soc. 2014;2014:410-3. doi: 10.1109/EMBC.2014.6943615.
This study examines the characteristics of the electric field (E-field) induced in the brain by electroconvulsive therapy (ECT) and magnetic seizure therapy (MST). The electric field induced by five ECT electrode configurations (bilateral, bifrontal, right unilateral, focal electrically administered seizure therapy, and frontomedial) as well as an MST coil configuration (circular) was computed in an anatomically realistic finite element model of the human head. We computed the maps of the electric field strength relative to an estimated neural activation threshold, and used them to evaluate the stimulation strength and focality of the various ECT and MST paradigms. The results show that the median ECT stimulation strength in the brain is 3-11 times higher than that for MST, and that the stimulated brain volume is substantially higher with ECT (47-100%) than with MST (21%). Our study provides insight into the observed reduction of cognitive side effects in MST compared to ECT, and supports arguments for lowering ECT current amplitude as a means of curbing its side effects.
本研究考察了电休克疗法（ECT）和磁休克疗法（MST）在大脑中诱发的电场（E场）的特征。在一个具有解剖学真实感的人体头部有限元模型中，计算了五种ECT电极配置（双侧、双额、右侧单侧、局灶性电惊厥治疗和额内侧）以及一种MST线圈配置（圆形）所诱发的电场。我们计算了相对于估计的神经激活阈值的电场强度图，并用它们来评估各种ECT和MST范式的刺激强度和聚焦性。结果表明，大脑中ECT刺激强度的中位数比MST高3至11倍，并且ECT刺激的脑体积（47 - 100%）比MST（21%）大得多。我们的研究为观察到的与ECT相比MST认知副作用减少提供了见解，并支持降低ECT电流幅度作为抑制其副作用手段的观点。
